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Image by rorozoa on Freepik Vaccine development has historically overlooked human leukocyte antigen (HLA) diversity, resulting in vaccines that may be effective for some populations but fail to provide sufficient protection across the globe. HLA genes are greatly polymorphic, with over 30,000 alleles around the world, and different ethnic groups exhibit distinct HLA frequencies. This … Continued

Experimental scheme of the proteogenomic immunopeptidome analysis workflow. From Chemla et al., 2025. “HLA export by melanoma cells decoys cytotoxic T cells to promote immune evasion.“ Cell (2025). doi: 10.1016/j.cell.2025.11.020; Licensed under the terms of the Creative Commons CC-BY 4.0 license. Melanoma remains highly lethal, with approximately 50% of patients resistant to immunotherapy despite the presence of tumour antigens … Continued

Overview of the PYE sample set and the study design. From Distler et al., 2025. “Multicenter evaluation of label-free quantification in human plasma on a high dynamic range benchmark set.“ Nat Commun 16, 8774 (2025). https://doi.org/10.1038/s41467-025-64501-z; Licensed under the terms of the Creative Commons CC-BY 4.0 license. Human plasma holds significant clinical potential as a liquid biopsy for disease … Continued

Schematic overview of the high-throughput hanging droplet workflow for micro-FFPE spatial proteomics. From Chen et al., 2025. “High-Throughput Spatial Proteomics at Cellular and Subcellular Resolution via a Hanging Droplet Workflow“, bioRxiv (2025): 2025-11. https://doi.org/10.1038/s41587-025-02791-w; Licensed under the terms of the Creative Commons CC-BY 4.0 license. Spatial proteomics has emerged as a powerful approach for mapping protein expression within intact … Continued

Overview of the alphaDIA framework. From Wallmann et al., 2025. “AlphaDIA enables DIA transfer learning for feature-free proteomics“, Nat Biotechnol (2025). https://doi.org/10.1038/s41587-025-02791-w; Licensed under the terms of the Creative Commons CC-BY 4.0 license. AlphaDIA is a new one-stop processing platform for raw DIA proteomics data. Introduced by Wallmann et al, from the Mann lab, AlphaDIA addresses challenges in processing … Continued

Graphical abstract. From Albrecht et al., 2025. “A Simplified Perchloric Acid Workflow With Neutralization (PCA N) for Democratizing Deep Plasma Proteomics at Population Scale“, Molecular & Cellular Proteomics, Volume 24, Issue 11, 101071; doi: 10.1016/j.mcpro.2025.101071. Licensed under the terms of the Creative Commons CC-BY 4.0 license. Large-scale plasma proteomics studies have been limited by a fundamental trade-off between … Continued